三甲糖-葡萄糖指数是否可以预测冠状动脉狂喜的诊断?
Ahmet Kivrak1, Yusuf Bozkurt Sahin1, Murat Akdogan1
1Department of Cardiology, Ankara Etlik City Hospital, Ankara, Türkiye.
Journal of clinical practice and research
|November 19, 2025
概括
胰岛素耐药性的标志物甘油三指数 (TyG) 在冠状动脉脱血症 (CAE) 患者中显著升高. 这一指数显示了作为CAE独立预测因子的潜力,即使在没有糖尿病的人群中也是如此.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 血管生物学 血管生物学
背景情况:
- 冠状动脉抽血 (CAE) 是一种血管疾病,需要有效的查方法.
- 胰岛素耐药性 (IR),由三甘油-葡萄糖 (TyG) 指数表示,与心血管疾病有关.
- 在非糖尿病患者中,TyG指数和CAE之间的关联仍未得到充分研究.
研究的目的:
- 在没有糖尿病 (DM) 的患者中调查TyG指数和CAE之间的独立关联.
- 评估TyG指数作为一种潜在的查工具,用于识别有CAE风险的个体.
主要方法:
- 追溯分析了1680名接受冠状动脉血管造影的患者 (92名CAE,1588名对照).
- 对人口,临床和生化数据的评估,包括TyG指数.
- 倾向性得分匹配 (PSM) 和多变量回归以确定独立预测因素.
主要成果:
- 与对照组相比,CAE组的TyG指数在PSM前后都明显高于对照组 (p<0.001).
- 多变量回归证实了TyG指数作为CAE的独立预测指标.
- 接收器操作特征 (ROC) 分析表明,PSM后的TyG指数的诊断性能有所改善.
结论:
- 在没有DM的患者中,提升的TyG指数水平与CAE显著相关.
- TyG指数作为CAE的潜在独立预测指标,对风险分层有价值.
- 这些发现强调了TyG指数在管理心血管健康和优化CAE查策略方面的临床实用性.
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