儿童性综合征中的类固醇反应和结果:来自约旦的多中心,横截面研究
Salma A Ajarmeh1,2, Kamal Akl3, Muna Al Shawabkeh4
1Department of Pediatrics, Mutah University, Karak 61710, Karak, Jordan.
World journal of clinical pediatrics
|November 19, 2025
概括
大多数患有性综合征 (NS) 的儿童对类固醇有反应,但很大一部分需要使用类固醇节约药物. 类固醇耐药NS (SRNS) 与更糟糕的结果有关,包括脏疾病和感染.
科学领域:
- 儿科脏病学 儿科脏病学
- 淋巴细胞疾病 淋巴细胞疾病
- 免疫抑制疗法 免疫抑制疗法
背景情况:
- 儿童性综合征 (NS) 呈现出由类固醇反应和并发症影响的可变结果.
- 了解这些因素对于有效管理至关重要.
研究的目的:
- 为了评估小儿性综合征中的类固醇反应率.
- 评估约旦儿童的治疗结果和使用类固醇节约剂的情况.
- 在这个人群中识别与NS相关的并发症.
主要方法:
- 在约旦,从2011年到2021年,对122名患有NS的儿童 (1-18岁) 进行了回顾性分析.
- 结果包括类固醇敏感性,依赖性,复发频率,CKD,ESKD,感染和类固醇节约治疗使用.
- 对脏活检数据进行了分析,以确定其病学发现.
主要成果:
- 81.1%的患者有类固醇敏感的NS;18.9%的患者有类固醇耐药的NS (SRNS).
- 最少的变化疾病是最常见的 (56.1%);焦点细分质硬化在SRNS中占主导地位 (82.6%).
- 41.8%需要使用类固醇节约药物;SRNS与感染,CKD和ESKD的增加有关.
结论:
- 在约旦,大多数儿科性综合征病例是对类固醇敏感的,主要组织学是疾病的最小变化.
- 类固醇耐药性性综合征与较差的结局和较高的并发症率有关.
- 类固醇节约药物经常是必要的,突出需要量身定制的治疗策略.
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