在移植接受者中,BK病毒感染和风险因素
Omer Faruk Akcay1, Asil Demirezen1, Cisem Cagdeser2
1Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Türkiye.
概括
BK病毒 (BKV) 感染是移植后的一个严重并发症. 吸烟和接受来自非亲属活体捐赠者的被确定为移植接受者BKV感染的关键独立风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病毒学 病毒学
- 移植免疫学 移植免疫学
背景情况:
- BK病毒 (BKV) 感染对移植 (KT) 接受者构成严重威胁,可能导致病和移植损失.
- 强度免疫抑制是已知的危险因素,需要进一步调查其他促成因素.
研究的目的:
- 调查移植患者中BKV感染的流行情况.
- 为了确定移植后BKV感染的相关风险因素.
主要方法:
- 一个回顾性队列研究,涉及322名KT接受者.
- BKV感染是由高水平的BK病毒病 (≥10^7副本/毫升) 或BKV相关的病症定义的.
- 使用单变量和多变量考克斯回归分析的风险因素.
主要成果:
- 在9.6%的患者中诊断出BKV感染,平均发病时间为8.7个月.
- 来自非亲属活体捐赠者的接受者,吸烟和氨酸抑制剂治疗在感染患者中更为普遍.
- 吸烟 (HR: 2.100) 和非亲属活体捐赠者 (HR: 4.243) 被确定为BKV感染的独立风险因素.
结论:
- 虽然免疫抑制是一个因素,但吸烟和非亲属的活体捐赠者是BKV感染的重要独立风险因素.
- 密切监测高风险接受者和戒烟对于减轻BKV感染风险至关重要.
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