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数字评估的长期COVID症状与淋巴细胞线粒体功能障碍和改变的免疫潜力有关

Vasile Mihai Sularea¹, Liam Townsend^2,3, Cian Reid¹

¹School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Open forum infectious diseases

|November 19, 2025

概括

长期COVID (LC) 患者表现出免疫细胞线粒体功能障碍和与症状严重程度相关的细胞因子产生变化. 这些发现表明潜在的生物标志物和COVID后疾病的治疗点.

科学领域:

免疫学免疫学免疫学
线粒体生物学线粒体生物学
病毒学病毒学

背景情况:

SARS-CoV-2 感染 (长期COVID) 的后急性后果是一种复杂的疾病,病理学不明.
在长期COVID中描述了代谢失调,但免疫细胞免疫代谢变化仍然不清楚.

研究的目的:

研究长期COVID患者循环免疫细胞中的免疫代谢变化.
为了将免疫细胞线粒体功能和细胞因子反应与长期COVID症状严重程度相关联.

主要方法:

对27名长期COVID患者和27名健康对照进行了临床,免疫和线粒体分析.
评估了淋巴细胞和单细胞中的线粒体功能 (质量,膜潜力).
刺激后的细胞因子产量 (IFN-γ,IFN-β,IL-10) 通过多重免疫测试进行测量.

主要成果:

与感染前状态相比,长期COVID患者报告了显著的症状负担.
在CD56bright自然杀手细胞 (头) 和CD4+淋巴细胞 (喘息) 中观察到线粒体膜潜力的降低.
在LPS刺激后,IFN-γ的产生受损,以及在R848刺激后,IFN-β/IL-10反应减少与特定症状有关.

结论:

长期COVID的症状严重程度与免疫细胞中的线粒体功能障碍有关.
长期COVID患者的改变细胞因子反应可能作为潜在的疾病生物标志物.
这些发现突出了长期COVID管理中未来治疗策略的潜在目标.

关键词:

免疫代谢过程中的免疫代谢.长时间的COVID.淋巴细胞淋巴细胞线粒体中的线粒体.自然杀手细胞的细胞.

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