探索同类氨酸的水平及其与注意力缺陷多动症障碍儿童认知功能的关系
Huiting Wang1,2, Ziqi Liu1, Xin Wang1
1Department of Pediatric Neurology, Capital Center For Children's Health, Capital Medical University, Beijing, China.
Frontiers in neurology
|November 19, 2025
概括
患有注意力缺陷多动症 (ADHD) 的儿童表现出更高的homocysteine水平,特别是年轻的男性. 然而,在这个ADHD队列中,高水平的同类氨酸与认知功能障碍没有相关性.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 生物化学 生物化学
背景情况:
- 注意缺陷多动症 (ADHD) 是一种神经发育障碍,通常与认知功能障碍有关,尽管其确切原因尚不清楚.
- 同类氨酸是一种已知的风险因素,与认知障碍有关.
研究的目的:
- 在被诊断患有多动症的儿童中检查血清同类半氨酸水平.
- 确定儿科多动症患者的同型半氨酸水平和认知功能之间的关系.
主要方法:
- 一项横截面的病例对照研究,涉及39名多动症儿童和40名健康对照.
- 使用酶循环方法测量血清同型半氨酸水平.
- 认知功能使用执行功能的行为评分清单 (BRIEF) 进行评估.
主要成果:
- 与健康儿童相比,患有多动症的儿童的血清总同型半氨酸水平显著更高 (p=0.002).
- 在患有ADHD的年轻 (p=0.001) 和男性 (p=0.010) 患者中,同类半氨酸的升高更为明显.
- 没有发现血清homocysteine水平和认知功能得分 (p>0.05) 之间的显著相关性.
结论:
- 患有ADHD的儿童表现出高水平的homocysteine,尤其是年轻的男性.
- 这项研究没有确定同类氨酸水平与ADHD儿童认知障碍之间的联系.
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