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综合生物信息分析揭示了多发性髓瘤患者的生存相关的枢纽基因和微RNA

Elham Hatef¹, Reza Bayat², Elahe Seyed Hosseini¹

¹Gametogenesis Research Center, Kashan University of Medical Science, Kashan, Iran.

Iranian journal of biotechnology

|November 19, 2025

概括

这项研究确定了参与多发性骨髓瘤 (MM) 进展和药物耐药性的关键基因和微RNA. 这些发现突出了CCND1,ITGB1,CREB1,miR-34c-5p和miR-155-5p作为改善MM患者结果的潜在治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

多发性骨髓瘤 (MM) 是一种B细胞恶性瘤,治疗选择有限.
改善MM治疗需要基本的分子洞察力.

研究的目的:

在多发性髓瘤 (MM) 中识别关键基因和microRNAs (miRNAs).
分析它们在疾病进展,预后和治疗耐药性的作用.

主要方法:

使用高通量测序重新分析的转录基因数据集 (GSE16558,GSE141260,GSE146649).
识别了差异表达基因 (DEGs) 和小RNA (DEMs).
进行了基因本体学 (GO),通路丰富和蛋白质-蛋白质相互作用 (PPI) 网络分析.

主要成果:

确定了13种在免疫细胞迁移,淋巴细胞激活和TGF-β信号传递中丰富的常见DEGs.
确定了CCND1,ITGB1和CREB1作为与生存显著相关的枢纽基因.
miR-34c-5p和miR-155-5p与亡和耐药性有关.

结论:

在MM中,基因变化和免疫微环境之间的复杂相互作用.
新生物标志物和MM管理的治疗目标的潜力.
改善治疗,预后和克服治疗耐药性的策略.

关键词:

生物信息学是一种生物信息学.基因基因基因基因基因基因基因本体学是基因的本体学.这是一个微型RNA.多发性骨髓瘤是一种多发性骨髓瘤.网络网络网络网络网络网络

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...