不常见的同伴:同时存在的T细胞大粒状淋巴细胞白血病和霍奇金淋巴瘤-A病例报告
Daniel van Tonder1, Brendon Roets2, Nicole Holland1
1Department of Haematopathology, Lancet Laboratories, Johannesburg, South Africa.
Case reports in hematology
|November 19, 2025
概括
本案例研究详细介绍了罕见的霍奇金淋巴瘤 (HL) 和T细胞大粒状淋巴细胞白血病 (T-LGLL) 的双重诊断. 它强调了诊断挑战和T-LGLL在复发性HLL中的潜在治疗诱导的演变.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 霍奇金淋巴瘤 (HL) 和T细胞大粒状淋巴细胞白血病 (T-LGLL) 的同时发生非常罕见.
- 双性淋巴瘤瘤具有显著的诊断和治疗复杂性.
研究的目的:
- 报告一个HL和T-LGLL同时存在的独特病例.
- 讨论双性淋巴细胞恶性瘤的诊断挑战和临床过程.
- 在HL治疗的背景下探索T-LGLL的潜在演变.
主要方法:
- 一个39岁的男性患有B型症状的病例报告.
- 用ABVD化疗和放射治疗治疗的IIIB阶段HL的诊断.
- 骨髓评估显示有异常T细胞表型和双克隆性的淋巴细胞瘤.
- 在治疗后和HL复发期间监测T细胞种群.
主要成果:
- 患者实现了HL的初始缓解.
- 骨髓显示治疗后持续的淋巴细胞瘤与克隆T细胞选择.
- 患者在近3年后再次出现HL.
- 复发与单克隆T-LGLL的骨髓透有关.
结论:
- 这个案例说明了HL和T-LGLL之间罕见的共存和潜在的相互作用.
- 对HL的治疗可能选择了先前存在的T-LGLL克隆.
- 需要进一步的研究,以了解这种双重瘤的发病和管理.
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