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Updated: Jan 11, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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通过SIRT2对HSC70的脱乙化促进了伴侣介导的自

Byunghyun Ahn1,2,3, Wenzhe Chen1,4, Wenbiao Shi1,5,6

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.

Autophagy reports
|November 19, 2025
PubMed
概括

脱乙酶SIRT2通过从HSC70中去除乙基来激活伴侣介导自 (CMA),从而增强饥饿期间的蛋白质降解. 这一发现揭示了细胞蛋白质稳定调节的原理.

关键词:
陪伴者介导的自细胞.在HSC70中,HSC70是KFERQ的图案是因为KFERQ的图案.在SIRT2中,SIRT2是SIRT2.氨基酸 饥饿 死亡脱乙化脱乙化热冲击的陪伴者 陪伴者lysosomes 溶解体 溶解体 是一种溶解体.蛋白质降解 蛋白质降解这里是Sirtuin.

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