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Updated: Jan 11, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

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适应性抑制MAPT转录 维持人体神经元发育中的陶蛋白质稳定

Mallory R Shin1, Narges Firouzshahi1, Gage Liddiard1

  • 1University of Iowa.

Research square
|November 19, 2025
PubMed
概括

当蛋白质清除失败时,神经元激活质量控制并减少tau的产生. 这种蛋白质稳定第一反应涉及对MAPT和神经元需求的转录抑制,为阿尔茨海默病等陶病症提供了目标.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.自自是自的过程.诱导多能干细胞 (iPS细胞) (iPSC) 是一种神经退行症的神经退行症神经发育的神经发育神经元神经元的神经元神经保护性神经保护剂蛋白质稳定症是一种蛋白质稳定症.蛋白 (tau) 是一种蛋白.病症是一种病症.乌比奎丁-蛋白酶体系统

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