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Updated: Jan 11, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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突变MAPT 在细胞模型中诱导rDNA转录过活化和核细胞应激

Zaid Muhammad1,2, Yan Gu2, Suleiman H Kwairanga1,2

  • 1Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.

Research square
|November 19, 2025
PubMed
概括

突变的蛋白积聚在细胞核中,增加其活性,导致细胞死亡. 这种核细胞功能障碍有助于前性痴呆症 (FTD) 中的神经毒性.

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