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Updated: Jan 11, 2026

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通过ATM介导的DNAJB11辅导体酸化促进了α-synuclein在DNA双链断裂上的折叠

Huan-Yun Chen1,2, Chia-Yu Liao2, Hsun Li1

  • 1Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

NAR molecular medicine
|November 19, 2025
PubMed
概括

双链断裂 (DSB) 在帕金森病 (PD) 中触发了α-synuclein聚合. 由DSBs激活的DNAJB11-HSP70通路为PD提供了一个新的治疗点.

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