在精神疾病中定义和参与一种新的rTMS目标对尼古丁渴望
Heather Burrell Ward1, Sophia H Blyth1, Simon Vandekar2
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
medRxiv : the preprint server for health sciences
|November 19, 2025
概括
在精神分裂症中吸烟与改变的默认模式网络 (DMN) 组织有关. 通过重复性横磁性刺激 (rTMS) 参与DMN,可以减少精神病患者对尼古丁的渴望.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 烟草使用是精神分裂症中可预防的死亡的主要原因,但其潜在机制尚不清楚.
- 以前的研究表明,尼古丁可能会使精神分裂症的默认模式网络 (DMN) 失调正常化.
- 双极性精神分裂症网络的中间表型2 (B-SNIP2) 队列提供了一个大样本来调查精神病谱系障碍.
研究的目的:
- 为了验证DMN组织与烟草使用之间的关联,在大规模的精神病频谱样本中进行验证.
- 评估单次和多次DMN向重复性跨脑磁性刺激 (rTMS) 对尼古丁渴望的影响.
主要方法:
- 对B-SNIP2队列 (n=596) 的横截面分析,以评估与吸烟状态相关的DMN连接性.
- 一个单一会话的rTMS研究 (n=10) 使用间歇性甲突破刺激 (iTBS),连续性甲突破刺激 (cTBS) 或假的,与前/后神经成像和渴望评估.
- 一个加快的,多次会议rTMS研究 (n=12) 使用DMN向cTBS超过5次会议,与前/后神经成像和渴望评估.
主要成果:
- 在B-SNIP2中,与以前和从未吸烟者相比,目前吸烟者表现出明显较低的DMN连接性,这在精神病亚组中是一致的发现.
- 单次会话的iTBS与渴望增加有关,而多次会话的DMN向cTBS在每次会话后显著减少了渴望,并降低了DMN连接.
- 结果表明,尼古丁使用与精神病中的DMN变化之间存在潜在的联系机制.
结论:
- 改变的DMN连接性与精神病患者的烟草使用有关.
- 针对DMN的重复性跨脑磁性刺激 (rTMS),特别是多次性cTBS,可能成为减少精神病中尼古丁渴望的新疗法目标.
- 需要进一步的研究来探索rTMS在这个人群中戒烟干预的治疗潜力.
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