前列腺癌多基因风险评分的验证和上下文影响在我们所有人的研究计划中
Shuyan Cheng1, Austin Hammermeister Suger1, Louisa B Goss2
1School of Public Health, University of Washington, Seattle, WA, USA.
medRxiv : the preprint server for health sciences
|November 19, 2025
概括
前列腺癌多基因风险评分 (PRS) 有效地在不同人群中分层风险. 它们的临床效用受到诸如体重指数,吸烟状况和最近获得医疗保健等因素的影响,而不是收入或教育.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 癌症流行病学 癌症流行病学
- 精准医学是一门精准的医学.
背景情况:
- 多基因风险评分 (PRS) 对前列腺癌风险分层有希望.
- 在不同的人口,生活方式和社会经济因素中,PRS的临床实用性仍然不清楚.
研究的目的:
- 在多样化的人口中验证多祖先前列腺癌PRS.
- 根据人口统计,生活方式和社会经济因素来评估PRS的上下文依赖性影响.
主要方法:
- 通过我们所有人研究计划 (7577例,90608例对照) 的数据验证了451种多种祖先前列腺癌PRS.
- 进行了祖先分层,年龄分层和多变量回归分析.
- 进行了一项全现象关联研究 (PheWAS),以评估PRS与其他临床结果的关联.
主要成果:
- 在6个遗传祖先组中,PRS与前列腺癌风险有很强的关联 (每SD的OR从1.61增加到2.19).
- 根据体重指数,吸烟状况和最近获得的医疗保健,PRS效应有所不同,但不是根据收入,教育或保险.
- 在PheWAS中,PRS与14种临床结果有关,包括与前列腺癌相关的疾病.
结论:
- 多祖先前列腺癌PRS是多种不同人群的强有力的预测因素.
- 人口,生活方式和医疗保健准入因素改变了PRS的临床实用性.
- 考虑这些上下文因素对于在临床和公共卫生环境中实施PRS至关重要.
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