超越外:探索核心外纳米纤维中的聚合物-脂质接口,以携带氨酸和β-caryophyllene
Aline Tavares da Silva Barreto1,2, Francisco Alexandrino-Júnior3, Bráulio Soares Arcanjo2,4
1Laboratório de Sistemas Híbridos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373 - Cidade Universitária, Rio de Janeiro - RJ, 21941-170, Brasil.
Beilstein journal of nanotechnology
|November 19, 2025
概括
研究人员开发了新的混合核心外纳米纤维,将氨酸和β-caryophyllene集成到一个聚乳酸外中. 这一突破为先进的生物医学应用提供了一个稳定的系统,克服了材料整合的挑战.
科学领域:
- 生物材料工程 生物材料工程
- 纳米技术纳米技术
- 聚合物科学 聚合物科学
背景情况:
- 氨酸 (HA) 和β-caryophyllene (βCp) 显示出治疗的前景,但面临着整合的挑战.
- 开发功能性纳米纤维系统需要创新的策略,以实现化合物兼容性和持续活动.
研究的目的:
- 设计和制造混合芯纳米纤维封装HA和β-caryophyllene纳米乳液 (NE-βCp).
- 为稳定和统一的纤维生产优化电参数.
- 描述生物医学应用的核心外结构和材料特性.
主要方法:
- 同轴电利用聚乳酸 (PLA) 作为HA和NE-βCp的外和核心.
- 系统优化电参数 (电压,流速,距离) 和环境条件 (湿度).
- 使用扫描电子显微镜 (SEM),共聚焦显微镜和横截面成像进行形态分析.
- 化学和热特性使用弱总反射率与里埃变换红外光谱学 (ATR-FTIR) 和热分析.
主要成果:
- 在优化条件下,产生了均的纳米纤维 (439 ± 100 nm直径),具有稳定的核心-外结构.
- 通过显微镜和光谱学证实了PLA外中HA和NE-βCp的成功集成.
- 纤维表现出表面的疏水性和增强的热稳定性.
- 在相对湿度低于45%的情况下实现了加工稳定性.
结论:
- 多功能纳米纤维膜的可行制造,将聚合物-脂质混合核心集成到PLA外中.
- 证明了先进生物医学应用的潜力,包括抗粘膜.
- 克服了组合HA和βCp输送系统的关键材料整合障碍.
相关概念视频
01:32Lipids as Anchors
7.1K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
7.1K
02:34Polymers
23.2K
23.2K
02:34Polymers
40.3K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.3K
01:35Asymmetric Lipid Bilayer
9.5K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
9.5K
01:23Glycosaminoglycans
6.8K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
6.8K