肠道微生物群对肠道疾病内镜干预后的结果的影响
Himanshu Agrawal1, Nitin Agarwal2, Nikhil Gupta3
1Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India.
World journal of gastrointestinal endoscopy
|November 19, 2025
概括
肠道微生物组显著影响内镜手术后的恢复. 有益的微生物有助于愈合,而失生症增加了并发症,为基于微生物组的个性化疗法铺平了道路.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 计算生物学 计算生物学
背景情况:
- 内镜干预对于胃肠道疾病管理至关重要.
- 诸如出血,感染和延迟愈合等并发症可能会对患者的治疗结果产生负面影响.
- 肠道微生物组在影响这些结果中的作用正在获得认可.
研究的目的:
- 评估肠道微生物群对后内镜干预后临床结果的影响.
- 专注于微生物多样性,特定种类,代谢功能和预测模型.
- 评估微生物组信息化策略的潜力,以改善患者的康复.
主要方法:
- 在PubMed,EMBASE和Cochrane数据库中进行系统的文献搜索,截至2025年5月.
- 包括分析肠道微生物组组成/功能与内镜干预和结果相关的人类研究.
- 使用16S rRNA基因测序,元基因组学和代谢学进行微生物组分析.
主要成果:
- 综述中包括了42项研究.
- 有益的微生物 (例如, *Faecalibacterium prausnitzii *, *Bacteroides spp. *) 已经被发现. *) 促进粘膜的愈合.
- 失生症 (例如,增加的 * 蛋白质细菌 *) 与更差的愈合和更高的并发症率相关.
- 基于微生物组的预测模型显示出预测并发症的潜力.
- 益生菌在恢复平衡和减少并发症方面表现有前途.
结论:
- 肠道微生物组显著影响内镜手术后的恢复.
- 将微生物组分析纳入临床决策可以个性化预测和治疗.
- 未来的研究应该标准化评估协议,并验证优化患者护理的预测模型.
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