病例报告:由tislelizumab引起的两个免疫相关心肌炎病例
Jie Zhao1, Jinliang Wan1, Shan Wang1
1Department of Oncology, Affiliated Hospital of Binzhou Medical College, Binzhou, China.
Frontiers in oncology
|November 19, 2025
概括
像tislelizumab这样的免疫检查点抑制剂可以在癌症患者中引起罕见但严重的免疫相关心肌炎. 早期识别和治疗对于控制这种可能致命的副作用至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 免疫检查点抑制剂 (ICI) 已成为癌症治疗的先进药物,但可能会导致与免疫相关的不良事件.
- 蒂斯莱利祖马布是一种用于治疗各种癌症的ICI.
研究的目的:
- 在接受tislelizumab治疗的患者中报告两例免疫相关心肌炎.
- 讨论tislelizumab诱导的心肌炎的机制,关联和管理.
主要方法:
- 两名癌症患者的病例报告 (直肠癌与肝转移,非小细胞肺癌) 用tislelizumab治疗.
- 对心脏酶标志物的临床观察和患者的结果.
- 关于免疫相关心肌炎的文献综述.
主要成果:
- 两位患者都表现出心脏酶标志物升高.
- 一名患者患上了致命的心肌炎;另一个患者在高剂量甲基prednisolone后得到改善.
- 来自ICI的免疫相关心肌炎很少见 (0.39%),但死亡率高 (>50%).
结论:
- 蒂斯莱利祖马布可以诱导免疫相关心肌炎,这是一个罕见但危及生命的不良事件.
- 及时诊断和适当的治疗,包括皮质类固醇,对于改善结果至关重要.
- 需要提高对这种副作用的临床意识,以便及时管理.
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