三级淋巴体结构支持过敏原特异性 CD4+ T 细胞原生细胞的发展
Derek J Bangs1, Brian Hondowicz1, Kathleen Abadie2
1Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
bioRxiv : the preprint server for biology
|November 19, 2025
概括
肺部的组织内存CD4+T细胞 (TRM) 存在于两个不同的群体中. 肺的三级淋巴体结构 (TLS) 作为祖细胞的,影响慢性炎症疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 组织内存CD4+T细胞 (TRM) 对于非淋巴细胞组织的适应性免疫至关重要.
- 这些细胞介导保护性反应,但也导致自身免疫和过敏性疾病.
研究的目的:
- 在暴露于室内灰尘虫后,研究肺部对过敏原特异性CD4+ TRM的异质性.
- 阐明肺三级淋巴体结构 (TLS) 在TRM分化和功能中的作用.
主要方法:
- 转录分析和流细胞测量以分析CD4+ TRM群体.
- 同焦点和空间转录组学以确定细胞局部化和转录状态.
- 对TLS开发的实验操作和PD1通路信号的评估.
主要成果:
- 确定了两个不同的CD4+ TRM群体:一种促炎的Th2血统和一种原始的TCF1+血统.
- 在呼吸道中发现了Th2细胞,而TCF1+细胞定位在TLS中,表明了不同的解剖学.
- 证实TLS是原始细胞,显示了从原始细胞到Th2细胞沿TLS:气道轴的转录梯度.
- TLS发育与TCF1表达相关,TLS内的TCF1+细胞对抗PD1治疗做出了反应.
结论:
- 肺部TLS作为 CD4+ TRM 的前体的关键,推动慢性过敏炎症的进展.
- 在TLS中的PD1通路影响TCF1+原始细胞.
- 针对TLS为慢性炎症性肺部疾病提供了潜在的治疗策略.
相关概念视频
Cells of the Adaptive Immune Response
8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K
Lymphoid Cells and Tissues
2.8K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.8K
Primary Lymphoid Organs
14.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.5K
T Cell Activation and Clonal Selection
14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
Secondary Lymphoid Organs
8.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.8K
Special Features of Adaptive Immunity
2.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.9K


