工作记忆扩展了大脑皮层中共享任务的表征
E Mika Diamanti1, Lucas Pinto2,3, Manuel Schottdorf1,4
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
bioRxiv : the preprint server for biology
|November 19, 2025
概括
认知负载灵活地重新配置神经活动组织. 工作记忆任务减少神经相关性,揭示了一个与认知需求扩展的共享的低维结构.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 认知依赖于灵活的神经活动组织.
- 了解神经表示如何随着认知负载而改变至关重要,但不清楚.
研究的目的:
- 调查工作记忆的表示与非工作记忆任务的区别.
- 探索不同认知负载的认知灵活性的神经基础.
主要方法:
- 在小鼠中使用虚拟现实任务切换范式.
- 同时对视觉 (AM) 和关联区域 (M2,后皮层) 的神经活动进行成像.
- 分析了单个神经元的活动,对对相关性和维度缩小.
主要成果:
- 单个神经元的活动看起来相似,但在工作记忆任务中,对对相关性下降,特别是在关联区域.
- 在任务中确定了一个共享的低维神经结构,根据认知负载,发射场组织不同.
- 在工作记忆任务中的不连接的射击场,特别是在关联区域,预测了对工作记忆的行为依赖.
结论:
- 认知需求是由一个单一的,可适应的低维神经结构支持的.
- 这种结构根据认知负载扩大或收缩,为皮层重构提供了一个框架.
- 神经表征可以动态重新配置,以支持不同任务中的认知过程.
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