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Updated: Jan 11, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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对pH敏感结合剂的计算设计

Green Ahn1,2,3, Brian Coventry1,2,3, Ella Haefner1,2

  • 1Institute for Protein Design, University of Washington, Seattle, WA, USA.

bioRxiv : the preprint server for biology
|November 19, 2025
PubMed
概括

科学家们开发了计算方法来设计pH依赖的蛋白质结合剂. 这些结合剂可以被设计为在酸性pH值下减弱或破坏稳定,从而为癌症等疾病提供新的治疗策略.

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