与年龄相关的皮质肌肉连接的重组在发动机乱期间
bioRxiv : the preprint server for biology
|November 19, 2025
概括
老年人表现出较少灵活的神经控制策略,依赖于更广泛的肌肉激活和较少特定的大脑区域通信与年轻人相比,在扰乱步行时. 这表明随着年龄的增长,人们正在转向以稳定为重点的运动控制.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 衰老研究研究 衰老研究
背景情况:
- 运动干扰会触发皮质和肌肉反应,以尽量减少运动错误.
- 衰老会改变神经控制策略,导致老年人反应不那么灵活,并产生补偿性过度活化.
- 了解皮质肌肉连接的年龄相关变化对于开发有针对性的干预措施至关重要.
研究的目的:
- 在年轻和老年人中,调查在乱的卧卧步行过程中皮质肌肉连接模式.
- 为了比较年龄组之间的神经和肌肉对机械干扰的反应.
- 为了识别运动控制任务期间大脑肌肉沟通的年龄相关差异.
主要方法:
- 使用高密度EEG和EMG来记录大脑和肌肉活动在扰乱步行.
- 应用独立组件分析,源定位和定向转移函数来分析皮质肌肉信息流.
- 在短暂的机械扰动期间,研究了theta,alpha和beta频段的连接性.
主要成果:
- 在干扰后,年轻成年人表现出缩的皮质源和强大的达频段同步,具有灵活的前带皮质连接.
- 老年人表现出较少的分化皮质源,最小的同步变化,以及更强的基线皮质肌肉连接.
- 年长的成年人依赖于涉及运动和后壁皮层的扩散连接模式,同时连接到多个肌肉.
结论:
- 衰老将神经控制从动态的,以错误驱动的策略重组为受约束的,以稳定为中心的方法.
- 乱的躺着步骤有效地揭示了年龄组之间的明显的皮质肌肉连接特征.
- 研究结果为旨在恢复老龄化和神经疾病患者的运动控制的康复干预提供了基准.
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