相关实验视频

Updated: Jan 11, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
10:59

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

10.1K

通过斑点局部化激酶TAOK2协调核RNA处理

Bridget E Begg, Matthew A Tracey, Shengyan Gao

    bioRxiv : the preprint server for biology
    |November 19, 2025
    PubMed
    概括

    激酶TAOK2通过化脚手架蛋白调节核斑结构和功能,影响细胞RNA处理和拼接. 这揭示了TAOK2的存在.

    更多相关视频

    Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection11:32

    Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection

    Published on: December 4, 2010

    15.8K
    Nonradioactive Assay to Measure Polynucleotide Phosphorylation of Small Nucleotide Substrates06:49

    Nonradioactive Assay to Measure Polynucleotide Phosphorylation of Small Nucleotide Substrates

    Published on: May 8, 2020

    5.1K

    相关概念视频

    Chromatin Structure Regulates pre-mRNA Processing02:41

    Chromatin Structure Regulates pre-mRNA Processing

    In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
    The chromatin structure, especially...
    8.1K
    Regulation of Nuclear Protein Sorting01:45

    Regulation of Nuclear Protein Sorting

    Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
    3.2K
    Additional Subnuclear Structures02:10

    Additional Subnuclear Structures

    The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
    The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
    5.2K
    Nuclear Export of mRNA02:31

    Nuclear Export of mRNA

    5.2K
    Nuclear Export of mRNA02:31

    Nuclear Export of mRNA

    Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
    8.6K
    Ribosomal RNA Synthesis02:53

    Ribosomal RNA Synthesis

    Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
    Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
    14.6K