内分类素信号传输是昼夜失调和代谢功能障碍之间的关键联系
Brennan A Baca1, Giancarlo E Denaroso1, Said Akli1
1Department of Psychological and Brain Sciences, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA, USA.
bioRxiv : the preprint server for biology
|November 19, 2025
概括
环境昼夜失同 (ECD) 通过大麻素受体1 (CB1r) 干扰新陈代谢. 肝脏CB1r信号传递对代谢激素干扰和基因表达变化至关重要,突出显示了它在代谢功能障碍中的作用.
科学领域:
- 代谢研究的研究.
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 循环节律的破坏与代谢失调有关.
- 这种联系背后的具体机制尚未完全理解.
- 内分泌大麻素系统在昼夜干扰效应中的作用尚未被探索.
研究的目的:
- 研究大麻素受体1 (CB1r) 在调解环境昼夜失同 (ECD) 的代谢效应中的作用.
- 阐明涉及到ECD诱导的代谢功能障碍的特定组织和机制.
主要方法:
- 使用野生型 (WT) 和CB1r淘汰 (KO) 鼠标模型,包括肝脏特异性的CB1r KO小鼠.
- 测量了血和肝脏中的内分泌大麻素水平 (AEA,2-AG).
- 评估了对ECD的代谢,行为和生理反应.
- 分析了与肝脏中氧化酸化相关的基因表达.
主要成果:
- ECD增加了血和肝脏中的AEA和2-AG水平.
- 全球CB1r KO保护免受ECD的代谢影响,尽管有类似的行为/生理反应.
- 肝脏特异性CB1r KO表明,肝脏CB1r调解ECD诱导的代谢激素干扰,但不是体重增加.
- 在WT小鼠肝脏中,ECD上调了氧化酸化基因转录,但在肝脏特异性的CB1rKO小鼠中没有.
结论:
- 由ECD引起的代谢功能障碍取决于大麻素受体1 (CB1r) 信号传递.
- 肝脏CB1r在调节代谢激素失调和改变基因表达以应对昼夜干扰方面发挥着至关重要的作用.
- 通过CB1r信号传递,ECD诱导特定组织的代谢变化,肝脏是关键器官之一.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
335
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
335
01:28Global Regulatory Systems
572
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
572
01:19Management of Insomnia
514
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
514
02:45Biological Clocks and Seasonal Responses
41.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.4K
01:08Chemical Signaling in the Endocrine System
6.0K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
6.0K