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特定于光滑肌细胞的TGFβ2可以保护小鼠免受胸前大动脉动脉瘤和解剖

Mengistu G Gebere, Mrinmay Chakrabarti, John Johnson

    bioRxiv : the preprint server for biology
    |November 19, 2025
    PubMed
    概括

    血管光滑肌细胞特异性TGFβ2对于保持大动脉壁完整性至关重要. 在小鼠中,其损失导致胸前大动脉动脉瘤,剖析和破裂,突出显示TGFβ2信号作为治疗点.

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    TGF - β Signaling Pathway01:16

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    The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...