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Updated: Jan 11, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Published on: February 25, 2022

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综合性多原子分析将TDP-43驱动的拼接缺陷与ALS/FTD路径的级联蛋白质原子破坏联系起来

Velina Kozareva, Zhengde Liu, Keyana Blake

    bioRxiv : the preprint server for biology
    |November 19, 2025
    PubMed
    概括

    丢失TDP-43蛋白质会扰乱RNA处理,导致神经元中的神秘外基因表达和蛋白质减少. 这项研究确定了关键的分子途径和潜在的治疗点,用于肌缩侧面硬化症 (ALS) 和前性痴呆症 (FTD).

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