相关实验视频

Updated: May 20, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

怀孕期间暴露于迷幻药物会破坏小鼠的大脑发育和后代的行为

Ya'el Courtney, Josephine M Anderson, Christian Lagares-Linares

bioRxiv : the preprint server for biology

|November 19, 2025

概括

母亲使用迷幻药物,如lysergic acid diethylamide (LSD),可能会影响胚胎发育. 产前暴露会影响大脑结构,并导致后代持续的神经发育和行为变化.

科学领域:

神经科学是一个神经科学.
发育生物学发展生物学
药理学药理学是指药理学的学科.

背景情况:

迷幻药的使用正在增加,但产前暴露的影响尚不清楚.
Lysergic acid diethylamide (LSD) 是一个著名的迷幻化合物.

研究的目的:

研究产前心理暴露对胚胎发育和后代神经生物学的影响.
为了确定母亲的LSD是否穿过胎盘并影响胚胎脑脊液 (CSF).

主要方法:

在怀孕期间,小鼠接受了 lysergic acid diethylamide (LSD) 的治疗.
在各种胚胎和产后阶段分析了脑脊液 (CSF) 和脑组织.
对成年后代进行了神经发育和行为评估.

主要成果:

母亲的LSD穿过胎盘并迅速进入胚胎的CSF.
暴露导致状,CSF蛋白质和皮层组织的变化.
产前LSD暴露导致神经元身份的改变,微质的增加和成年后代的行为缺陷,主要是男性.

结论:

冠状动脉作为一个界面检测母亲的迷幻药物.
通过CSF获取产前迷幻药物暴露会导致持久的神经发育和行为后果.
研究结果强调了孕妇在怀孕期间使用迷幻药所带来的风险.

更多相关视频

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...