白物质中不对称的生命周期轨迹
Praitayini Kanakaraj1, Sam Bogdanov2, Michael E Kim1
1Vanderbilt University, Department of Computer Science, Nashville, TN, USA.
bioRxiv : the preprint server for biology
|November 19, 2025
概括
大脑白质不对称性是普遍存在的,并且在一生中会发生变化. 这项研究对26,199个人的30个途径进行了这些变化的绘图,揭示了大脑侧向化独特的发育和衰老轨迹.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑发育 人类大脑发育
- 神经成像是一种神经成像.
背景情况:
- 白质不对称对于认知专业化和大脑横向化至关重要.
- 之前关于白质不对称性的研究范围,年龄范围和样本大小有限.
- 缺乏对白质不对称性的全面寿命图表.
研究的目的:
- 为了描述整个生命周期的白质不对称性.
- 检查30个白质片的微观结构和宏观结构特征.
- 为白质不对称性提供规范性寿命轨迹.
主要方法:
- 利用来自42个神经成像研究的26,199名个人 (0-100年) 的大规模数据集.
- 分析了30个横向白质道的14个微观结构和宏观结构特征.
- 产生了白质不对称的寿命轨迹.
主要成果:
- 在所有30个途径中观察到广泛的白质不对称性.
- 在路径内的微观结构和宏观结构特征之间,不对称性模式有所不同.
- 不对称性在协会和投影轨道之间和内部各不相同.
- 不对称性表现出独特的寿命轨迹,通常随着年龄的增长而增加,特别是在晚年成年时.
结论:
- 这项研究提供了对整个寿命的白质不对称性的最广泛的描述.
- 这些发现为了解大脑组织,功能专业化和衰老提供了基础资源.
- 这些数据作为解释健康和临床人群偏差的参考.
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