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Updated: Jul 26, 2026

Generation of Neural Stem Cells from Discarded Human Fetal Cortical Tissue
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在唐氏综合征中皮质神经发生的加速速度

Jingwen W Ding1,2, Chang N Kim3,4, Marilyn R Steyert3,4

  • 1The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.

bioRxiv : the preprint server for biology
|November 19, 2025
PubMed
概括

三胞体21 (TS21) 加快了唐氏综合征 (DS) 中的神经干细胞的进展,导致抑制性神经元和寡干细胞的早期产生. 这将遗传变化与改变的大脑细胞组成和潜在的治疗点联系起来.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...