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Updated: Jul 16, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

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一个微工程心脏组织模型的Desmin相关心肌病由突变αB晶体素引起

Yasaman Kargar Gaz Kooh1, Bahareh Bahmani2, Chen Zhao3,4

  • 1Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.

bioRxiv : the preprint server for biology
|November 19, 2025
PubMed
概括

研究人员使用基因组编辑细胞开发了一种新的Desmin相关心肌病 (DRM) 模型. 该模型在自然水平上表达突变的α结晶B链 (CRYAB),揭示了疾病机制,并确定了JAK1抑制作为潜在的治疗方法.

关键词:
心肌病性心脏病 - 心肌病性心脏病陪伴者蛋白质 陪伴者蛋白质工程微型心脏组织.人类的iPSC.

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