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Updated: Jan 11, 2026

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

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在视网膜发育过程中,METTL3将染色质可访问性从转录分离

Jing Xu, Yuanhao Huang, Zhaowei Han

    bioRxiv : the preprint server for biology
    |November 19, 2025
    PubMed
    概括

    甲基转移酶类3 (METTL3) 通过调节RNA代谢,对视网膜发育至关重要. 它的表体转录功能通过m6A修饰影响视网膜前细胞分化和基因稳定性.

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    Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation07:38

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    Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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    In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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