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Updated: Jan 11, 2026

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
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Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

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乳酸脱酶缺乏的癌细胞对Ym155诱导的DNA损伤的敏感性增加

Qianjin Guo, Sooyeon Lee, Neali Armstrong

    bioRxiv : the preprint server for biology
    |November 19, 2025
    PubMed
    概括

    患有SDHB缺乏症的遗传性叶红细胞瘤和偏角细胞瘤 (hPPGL) 患者表现出转移风险增加. 这项研究确定Ym155是一种强大的治疗剂,通过诱导DNA损伤,证明了对SDHB缺乏癌症的显著细胞毒性.

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