精神分裂症,变异性,以及安娜·卡列尼娜原则
Michael Murphy1,2, Dost Öngür1,2
1McLean Hospital; Belmont, MA, 02447, USA.
bioRxiv : the preprint server for biology
|November 19, 2025
概括
由于神经干扰增加,精神分裂症患者群体的变异性更高,不一定是特定的疾病因素. 这种异质性,而不仅仅是病理,解释了神经成像研究中观察到的差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物统计学 生物统计学
背景情况:
- 神经成像研究显示,与对照人群相比,精神分裂症患者的群体内变异性更高.
- 在临床定义的群体中,这种高差异是违反直觉的,需要解释.
研究的目的:
- 为了调查精神分裂症神经成像研究中偏差升高的原因.
- 为了确定异质性和扰动是否占比,而不是特定的病理,解释观察到的差异.
主要方法:
- 利用了来自精神分裂症患者和对照组的模拟和真实神经成像数据.
- 开发了以扰动计数为重点的模型,以评估它们复制观察到的变异的能力.
主要成果:
- 证明,由于精神分裂症患者的神经干扰的总数较高,在无关变量中可以出现较高的方差.
- 显示仅基于扰动计数的模型可以复制在精神分裂症人群中观察到的高差异.
结论:
- 在所有分析水平上,精神分裂症的固有异质性足以导致患者群体的高差异.
- 精神分裂症研究中的标准统计方法可能会因这种异质性而混.
- 减少可能与贫困相关的广泛破坏性因素,可能比针对特定病理更有效地预防精神分裂症.
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