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Updated: Jan 11, 2026

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

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合成信号平台发现并重新连接细胞对PD-1扰动的反应

Zhixing Ma1,2,3, Lars Hellweg1,2, Susanna K Elledge1,2,4

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

bioRxiv : the preprint server for biology
|November 19, 2025
PubMed
概括

科学家们开发了Sphyder (选择性酸铁检测和重新连接) 来检测和重新编程细胞信号. 这种新方法揭示了PD-1受体的动态,并使新型免疫检查点抑制剂的工程成为可能.

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Interactions Between Signaling Pathways01:19

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Amplifying Signals via Enzymatic Cascade

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
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Assembly of Signaling Complexes

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Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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