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Updated: Jan 11, 2026

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综合应激反应途径改善老鼠肌肉干细胞激活和in vivo再生

Alexander D Brown^1,2, Annarita Scaramozza^1,3, Hanzhi Zhang¹

¹The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

bioRxiv : the preprint server for biology

|November 19, 2025

概括

综合应激反应 (ISR) 途径调节肌肉干细胞 (MuSC) 的激活. 激活老年MuSC中的ISR可以改善它们的功能和肌肉再生,为抗衰老提供治疗潜力.

科学领域:

肌肉干细胞生物学肌肉干细胞生物学
衰老的研究研究.
再生医学是一种再生医学.

背景情况:

肌肉干细胞 (MuSCs) 对于肌肉再生至关重要.
衰老延迟了MuSC的激活,影响了组织的修复.
早期 MuSC 激活状态的分子调节者尚不清楚.

研究的目的:

为了确定 MuSC 过渡状态的分子调节者.
调查综合应激反应 (ISR) 途径在 MuSC 衰老中的作用.
评估ISR激活对老年肌肉再生的治疗潜力.

主要方法:

单细胞RNA测序 (scRNA-Seq) 和细胞染色试验.
对MuSC异动性和转录状态的分析.
在体外和体内对老年小鼠药理学ISR激活的研究.

主要成果:

该ISR路径批判性地调节了MuSC过渡状态.
陈旧的MuSCs表现出较高的基线ISR活性.
药理ISR激活增强了老年MuSC激活,迁移和转录特征.
在体内,ISR激活改善了老年MuSC的功效和肌肉再生.

结论:

该ISR通路是MuSC衰老和功能的关键调节者.
针对ISR途径可以使老年MuSCs复苏.
药物学ISR激活显示了与年龄相关的肌肉衰退和修复的治疗前景.

关键词:

衰老的衰老衰老的衰老伊斯里布伊斯里布萨尔003是什么意思 Sal003是什么意思激活动态的激活动态综合应激反应综合应激反应肌肉干细胞是肌肉的干细胞.国家过渡状态过渡

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