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岛屿输入到前临床皮层是大鼠社会情感行为的基础

E K Chun¹, A Djerdjaj¹, T Matulis¹

¹Department of Psychology & Neuroscience, Boston College, 140 Commonwealth Ave, Chestnut Hill, MA 02460.

bioRxiv : the preprint server for biology

|November 19, 2025

概括

老鼠使用insula-prelimbic皮质电路来决定是否接近或避免压力大的社会伙伴. 这种社会决策途径对于导航复杂的社会互动至关重要.

科学领域:

神经科学是一个神经科学.
社会行为社交行为
决策决策决策决策

背景情况:

社会互动需要基于同类信息的行为调整.
突出网络,包括前临床 (PL) 皮层和岛屿 (IC),整合了决策的社会线索.
了解社会决策的神经基础至关重要.

研究的目的:

为了研究岛外前极皮质 (IC-PL) 电路在社会情感偏好 (SAP) 测试中的作用.
确定特定IC和PL路径在社会接近/回避行为中的必要性.

主要方法:

使用社会情感偏好 (SAP) 测试与压力和天真的老鼠.
采用了局部和管道特定的功能丧失方法来禁用神经回路.
使用化学遗传学来抑制IC所准的PL神经元.

主要成果:

PL皮质,前部IC和连接IC与PL的通道对于老鼠决定接近或避免压力较大的同类是必不可少的.
抑制IC-innervated PL神经元破坏了社会情感行为.
证明了IC-PL电路在调解社会方法避免方面的必要性.

结论:

在社会决策中建立了岛屿和前额回路之间的机制联系.
突出了IC-PL电路在处理社会压力线索和指导行为方面的重要性.
提升了对社会信息处理背后的神经生物学的理解.

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