结核病中的益生菌补充:一个范围审查
Tejaswini Baral1, Mohan K Manu2, Kavitha Saravu3
1Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Scientifica
|November 19, 2025
概括
益生菌作为结核病 (TB) 患者的补充疗法具有前景,有可能在密集治疗期间减少副作用. 需要进一步的研究来证实长期益处.
科学领域:
- 微生物学 微生物学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 结核病 (TB) 治疗包括密集的抗结核疗法 (ATT),这可能导致药物不良反应.
- 肠道微生物群失生症在结核病患者中越来越被认可.
- 益生菌,即带有健康益处的活微生物,正在探索它们在各种疾病中的治疗潜力.
研究的目的:
- 对目前关于使用益生菌作为结核病 (TB) 辅助治疗的临床证据进行范围审查.
- 综合结核病治疗期间益生菌的疗效和安全性的研究结果.
- 发现现有研究中的差距.
主要方法:
- 在PubMed,Scopus和Embase进行了系统的文献搜索.
- 包括在2016年至2023年期间发表的涉及结核病患者益生菌的研究.
- 总共有六项研究符合本次审查的纳入标准.
主要成果:
- 在ATT的强化阶段,补充了益生菌,持续时间为38周.
- 在这六项研究中,有五项专注于肺结核.
- 益生菌在减轻胃肠道和肝脏不良药物反应,调节肠道微生物群,增强屏障功能和影响免疫反应方面表现出潜力.
结论:
- 益生菌在结核病ATT强化阶段是潜在的辅助疗法.
- 观察到的好处包括减轻药物诱导的副作用和调节宿主反应.
- 结核病中益生菌的长期影响和持续益处需要通过精心设计的纵向研究进行进一步的研究.
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