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相关概念视频

Kidney Structure01:45

Kidney Structure

74.7K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
74.7K
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

5.9K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
5.9K
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

246
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
246
Renal Corpuscle01:20

Renal Corpuscle

6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

3.3K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.3K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

3.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.0K

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相关实验视频

Updated: Jan 11, 2026

Whole-Kidney Three-Dimensional Staining with CUBIC
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Whole-Kidney Three-Dimensional Staining with CUBIC

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基细胞+:用于解码生物学的多模式单细胞基础模型.

Chenyu Li, Elias Ziyadeh, Yash Sharma

    ArXiv
    |November 19, 2025
    PubMed
    概括

    尼基细胞+是第一个脏特异性的基础模型,在单细胞脏分析中表现优于现有的方法. 这种先进的模型使基因组学研究能够进行强大的跨物种比较.

    科学领域:

    • 单细胞基因组学 单细胞基因组学
    • 计算生物学是一种计算生物学.
    • 生物医学数据科学是生物医学数据科学.

    背景情况:

    • 基金会模型有先进的单细胞分析,但缺少脏特定模型.
    • 现有的模型在脏复杂的细胞性,批量效应和跨物种数据集成方面扎.

    研究的目的:

    • 开发第一个以脏为重点的大型基础模型.
    • 评估器官特异性模型是否超过脏数据的通用化模型.

    主要方法:

    • 开发了Nephrobase Cell+,一种基于变压器的编码器解码器模型.
    • 从39.5万个单细胞/细胞核概况中预先训练了约1000亿个令牌.
    • 整合了基因令牌交叉注意力和专家混合模块.

    主要成果:

    • 尼基细胞+实现了人类和小鼠细胞的卓越嵌入.
    • 证明了高集群一致性和有效的批量效应去除.
    • 展示了>90%的零射击注释准确度和强大的跨物种对齐.

    结论:

    • 基细胞+提供了一个统一的,高准确度的生物学表现.

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  • 该模型是强大的,跨物种可转移,优于现有的基础模型.
  • 为基因组学和疾病研究提供了强大的资源.