在患有牛皮的患者中,索尔提林是亚临床动脉样硬化的指标吗?
Gamze Taş Aygar1, Bengü Çevirgen Cemil1, Hatice Kaplanoğlu2
1Department of Dermatology, University of Health Sciences, Etlik City Hospital, Ankara, Türkiye.
概括
血清索尔蒂林可能表明牛皮患者的亚临床动脉样硬化. 虽然整体索尔提林水平没有差异,但与动脉内心介质厚度的相关性表明,它在这个人群中具有作为心血管风险生物标志物的潜力.
科学领域:
- 心脏病学 心脏病学
- 皮肤病学 皮肤病学
- 生物标志物研究 生物标志物研究
背景情况:
- 牛皮与心血管事件增加有关,包括动脉样硬化.
- 亚临床动脉样硬化评估对于牛皮患者的风险分层至关重要.
研究的目的:
- 在牛皮患者中研究血清利林作为亚临床动脉样硬化症的潜在生物标志物.
主要方法:
- 在33名牛皮患者和33名对照人群中,酶相关免疫吸收试验 (ELISA) 检测血清索尔蒂林.
- 通过超声波测量动脉内部介质厚度 (CIMT) 和大腿内部介质厚度 (FIMT).
- 评估代谢参数,疾病严重程度 (PASI) 和人口统计数据.
主要成果:
- 牛皮患者和对照人群 (p=0.729) 之间的血清索尔蒂林水平平均没有显著差异.
- 与对照组相比,牛皮患者的右和左CIMT显著增加 (p=0.012,p=0.020).
- 在牛皮患者的血清索尔蒂林水平和正确的CIMT之间观察到显著的正相关性 (p=0.031).
结论:
- 血清索尔蒂林可以作为银病患者亚临床动脉样硬化的指标.
- 索尔蒂林和CIMT之间的相关性突显了它在评估这一队列中心血管风险方面的潜在作用.
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