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在虚拟查指导下发现小分子CHI3L1抑制剂,在质母细胞瘤球状体中具有功能性活性

Baljit Kaur1, Katrin Denzinger2, Longfei Zhang1

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.

ACS medicinal chemistry letters
|November 19, 2025
PubMed
概括

研究人员确定了新型小分子抑制剂,用于基因酶-3样蛋白1 (CHI3L1),这是质母细胞瘤 (GBM) 的关键标. 化合物8在GBM治疗中显示出有希望的疗效和药理动力学特性.

关键词:
3D 药物鉴定器 3D 药物鉴定器生物物理验证验证CHI3L1 的意思是药物发现 药物发现 药物发现虚拟查 虚拟查

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