前列腺癌中的丸激素替代:新兴范式和治疗潜力的系统审查
Jared Robinson1, Indrajit Banerjee2, Indraneel Banerjee3
1Surgery, Joe Morolong Memorial Hospital, Vryburg, ZAF.
Cureus
|November 19, 2025
概括
替代疗法 (TRT) 不适用于治疗前列腺癌的男性. 研究表明,TRT不会恶化前列腺癌,并且可以改善治疗后的阴茎下垂男性的生活质量.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 前列腺癌是老年男性的流行癌症,受遗传,环境和种族因素的影响.
- 雄激素和前列腺敏感性与前列腺癌的发展有关.
- 传统的治疗方法包括手术,辐射和抗雄激素剥夺疗法 (ADT).
研究的目的:
- 系统地审查替代疗法 (TRT) 与前列腺癌之间的关系.
- 挑战TRT在前列腺癌患者中的常规禁忌.
- 为了澄清TRT在前列腺癌管理中的作用.
主要方法:
- 在Google学者,旅行数据库,EMBASE,PubMed和PubMed中央系统的文献审查.
- 使用的关键词:"激素替代疗法"",前列腺"",前列腺瘤"",丸激素"",泌尿学".
- 数据提取的重点是整理最新的可用信息.
主要成果:
- 在已完成前列腺癌终极治疗的男性中,外源性TRT并非禁忌.
- TRT不会改变前列腺内脱水氨 (DHEA) 水平,也不会影响前列腺环境.
- 高剂量的TRT并没有导致割抵抗性前列腺癌的疾病进展.
结论:
- TRT与前列腺癌之间没有相关性;TRT在最终治疗后并非禁忌.
- 在初级治疗后,TRT适用于阴茎缺陷男性,改善生活质量.
- 前列腺癌诊断前TRT的作用尚不清楚;知情同意至关重要. 双极性雄激素治疗 (BAT) 在晚期前列腺癌中显示出潜力.
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