女性夜班工作者喘风险增加
Robert J Maidstone1, David W Ray2,3,4,5, Junxi Liu6
1Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
ERJ open research
|November 19, 2025
概括
轮班工作在女性中比男性更能增加喘风险. 在不使用激素替代疗法 (HRT) 的绝经后妇女中,这种风险特别高.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 女人和夜班工人中喘的患病率更高.
- 轮班工作中女性参与度的增加需要调查轮班工作相关喘的性别特异性风险.
研究的目的:
- 为了确定轮班工作频率的增加是否与男性相比,与女性患喘的普遍性更强烈相关.
- 探索潜在的机械洞察力,包括时间型,性激素和更年期状态.
主要方法:
- 利用了来自28万多名英国生物库参与者的横截面数据.
- 采用调整了人口统计和生活方式因素的后勤回归模型来分析与轮班工作频率相关的喘表型的性别差异.
- 研究了与时间型,性激素和更年期的关联,以了解机械学.
主要成果:
- 与白天工作的女性相比,女性永久夜班工人患中度至重度喘的几率显著更高 (OR 1.50),男性没有发现类似的关联 (OR 0.95;性别相互作用p=0.01).
- 这些关联与"所有喘"和"喘息或胸部吹口哨"表型一致.
- 妇女的风险增加主要观察到不使用激素替代疗法 (HRT) 的绝经后妇女 (调整后OR1.89),HRT使用者的风险减少.
结论:
- 轮班工作频率的增加与女性比男性更强烈地与喘有关,这表明这是一个重大的公共卫生问题.
- 需要进行进一步的干预研究,以探索修改轮班工作时间表或使用HRT在减轻女性喘风险方面的有效性.
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