相关实验视频

Updated: Jan 6, 2026

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

健康人群对曼尼托尔的气道反应

Heikki O Koskela^1,2, Anne M Lätti^1,2, Hanna M Nurmi^1,2

¹Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

ERJ open research

|November 19, 2025

概括

个体特征不会显著影响健康成年人的曼尼托尔气道反应能力. 正常反应的上限在个体之间是一致的,尽管在轻度反应中可重复性很差.

科学领域:

呼吸系统医学呼吸系统医学
肺功能测试试验肺功能测试
气道的超响应性气道的超响应性

背景情况:

对影响曼尼托尔呼吸道反应的因素的理解有限.
关于健康个体的正常反应极限和可再生性的不确定性.

研究的目的:

调查受试者特征对气道对曼尼托尔反应效应的影响.
为了确定正常曼尼托尔反应的上限.
评估曼尼托尔气道反应性测试的可重复性.

主要方法:

125名健康的,不吸烟的成年人 (18-82岁) 接受了曼尼托尔测试.
通过FEV1的最终下降 (FFALL) 和响应与剂量比率 (RDR) 来衡量气道反应.
25名受试者重复了测试以评估可重现性.

主要成果:

年龄,性别,BMI,阿托皮和基线FEV1并没有显著影响曼尼托尔的反应.
对FFALL的上限为13.4%;对RDR的上限为每100mg的1.96%.
类内可重现性的相关系数为0.46 (FFALL) 和0.35 (RDR).

结论:

个体的特征不会显著改变曼尼托尔气道的反应性.
曼尼托尔正常反应的确定的上限适用于所有成年非吸烟者.
温和的曼尼托尔气道反应表明健康人体的复制性不佳.

更多相关视频

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Published on: July 4, 2018

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

相关概念视频

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...

Regulation of Water Intake

Regulation of Water Intake

Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...