在2型糖尿病患者中查代谢功能障碍相关的脂肪性肝病:我们做得够好了吗?
Sun H Kim1,2, Gavin Hui3, C William Pike3
1Division of Endocrinology, Gerontology and Metabolism, Stanford University, Palo Alto, CA.
Diabetes spectrum : a publication of the American Diabetes Association
|November 19, 2025
概括
在2型糖尿病患者中使用FIB-4指数查肝纤维化正在增加,但仍然不完整. 为了更好地管理与代谢功能障碍相关的脂肪性肝病,需要进一步改进实验室测试和药物坚持.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 临床实践研究 临床实践研究
背景情况:
- 患有2型糖尿病的患者面临更高的代谢功能障碍相关的脂肪性肝病 (MASLD) 和晚期肝纤维化风险.
- 专业指南建议使用纤维化-4 (FIB-4) 指数来对这种人群进行初始肝纤维化查.
研究的目的:
- 评估2型糖尿病患者FIB-4指数计算所需的实验室测试频率.
- 评估遵守推的肝脏健康监测和管理策略.
主要方法:
- 对337,094名40至75岁的2型糖尿病患者的电子病历进行了回顾性分析.
- 对FIB-4评分组件,尿蛋白测量和他类药物使用的检查完成率.
主要成果:
- 只有33%的患者具有FIB-4计算所需的所有组件,尽管这一比例从2010-2014年到2020-2024年大幅增加.
- 尿蛋白测量仍然很低 (13%) 尽管增加.
- 达丁类药物和较新的抗高血糖药物处方显示显著增加.
结论:
- 对于2型糖尿病患者来说,肝脏健康检测的频率正在改善,但仍然存在显著的临床实践差距.
- 需要继续努力,以确保在这个高风险群体中全面查和治疗肝病.
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