老年人营养风险指数预测治疗不耐受性和头癌的存活率
Raisa Chowdhury1, Alex M Mlynarek2, Keith Richardson2
1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
Head & neck
|November 19, 2025
概括
营养不良影响头癌 (HNC) 的结果. 老年营养风险指数 (GNRI) 预测可手术的HNC患者的生存率和治疗不耐受性更差.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 手术瘤学手术瘤学
背景情况:
- 营养不良是头癌 (HNC) 患者不良结果的已知预测因素.
- 老年营养风险指数 (GNRI) 是评估营养状况和预测结果的潜在工具,但它在HNC中的特定作用需要进一步研究.
研究的目的:
- 评估手术前老年营养风险指数 (GNRI) 对手术后发病率,死亡率和生存率的预测值,用于手术治疗头癌 (HNC) 的患者.
主要方法:
- 一项雄心勃勃的研究包括从2015年到2024年在两个学术中心接受HNC手术的312名以前没有接受过治疗的患者.
- 手术前的GNRI得分分类为中度至高风险 (<92),低风险 (92-98) 和无风险 (>98).
- 评估的结果包括90天死亡率,治疗不耐受性,整体存活率和无病存活率,并根据相关临床和人口统计因素调整了分析.
主要成果:
- 与没有风险的患者相比,中度至高GNRI风险 (13%) 的患者出现较高的重大不良事件率 (57%vs36%) 和治疗不耐受性 (61%vs41%).
- 多变量分析显示,中度至高的GNRI风险与90天死亡率 (OR 2.99) 和治疗不耐受性 (OR 2.35) 的增加几率有显著关联.
- 考克斯回归表明,较低的GNRI得分预测了明显较短的整体存活 (HR 2.28) 和无病存活 (HR 1.87).
结论:
- 术前老年营养风险指数 (GNRI) 是预测治疗不耐受性和可手术头癌 (HNC) 患者的较差生存结果的宝贵工具.
- 将GNRI评估纳入术前评估可能有助于识别高风险HNC患者,他们可以从有针对性的营养干预中受益.
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