超重对25-基维生素D水平的影响
1Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Türkiye.
Turkish archives of pediatrics
|November 19, 2025
概括
超重儿童的维生素D缺乏率更高. 然而,关键的维生素D生物标志物,如副甲状腺激素 (PTH) 和水平在体重组之间是相似的,这表明统一的摄入建议.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养生物化学 营养生物化学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 超重的儿童往往有较低的血清25-基维生素D (25(OH) D).
- 儿童体重类别之间的维生素D概况的生物化学差异尚未得到充分理解.
- 这项研究调查了与儿童体重状况相关的与维生素D相关的生化标志物.
研究的目的:
- 评估血清25(OH) D,副甲状腺激素 (PTH),性酸酶 (ALP),白蛋白,,和与儿童的体重状况有关.
- 为了确定与维生素D相关的生物化学概况是否在有超重和没有超重的儿童之间有所不同.
- 了解儿童群体中维生素D状态和关键生化标志物之间的关系.
主要方法:
- 对544名儿童和青少年 (1-18岁) 进行了回顾性横截面分析,这些儿童和青少年的25...OH) D水平较低.
- 参与者根据BMI百分位被分为超重和正常体重组.
- 分析了血清中25(OH) D,PTH,ALP,白蛋白,,和的含量.
主要成果:
- 超过一半 (55.9%) 的参与者超重/肥胖,维生素D缺乏的患病率更高 (P = .024).
- 在体重组之间,25 ((OH) D,PTH,ALP,白蛋白,,和的平均度是可比的.
- 维生素D缺乏与较高的PTH和较低的相关;过重与不足子组内较高的PTH有关.
结论:
- 与维生素D状况相关的生物化学标志物在缺乏或不足的儿童中,在体重类别中基本相似.
- 这些发现支持目前对所有儿童维生素D和摄入量的建议,无论体重如何.
- 在这个儿科队列中,体重状况并没有显著改变与维生素D状况相关的生化特征.
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