流感的转变趋势和HBoV病例的增加:对3个冬季的比较分析
Meltem Cetin1, Caner Turan2, Ceren Yurumez3
1Faculty of Medicine, Department of Pediatrics, Division of Emergency Medicine, Faculty of Medicine, Ege University, Bornova, Izmir, 35100, Turkey.
BMC infectious diseases
|November 19, 2025
概括
随着COVID-19大流行,儿科呼吸道病毒模式发生了转变,增加了人类口腔病毒1 (HBoV1) 的流行率,同时降低了流感. 单独的HBoV1不会导致严重的疾病,但同时感染会增加儿科急性呼吸道感染 (ARTI) 发病率.
科学领域:
- 儿童传染病 儿童传染病
- 病毒感染的流行病学.
- 公共卫生和病毒学.
背景情况:
- 急性呼吸道感染 (ARTIs) 是儿童住院治疗的重要原因之一.
- 随着COVID-19大流行,呼吸系统病毒的循环发生了变化,包括流感和人类口腔病毒1 (HBoV1).
研究的目的:
- 调查大流行病对小儿ARTIs中HBoV1患病率的影响.
- 分析HBoV1在流行病后期的临床影响.
主要方法:
- 一项回顾性队列研究分析了流行病前 (2017-2019) 和流行病后 (2022-2024) 冬季的儿科急诊室数据.
- 多重PCR在鼻抽样中发现了呼吸道病毒.
- 评估了临床数据,住院率和疾病严重程度.
主要成果:
- 在大流行后,HBoV1的患病率显著增加 (9.5%至20.8%),而流感A/B的患病率则下降.
- 同感染总体下降,但与HBoV1.1有很强的关联.
- 严重的疾病与同时感染 (aOR:7.3) 和年轻 (≤1年,aOR:2.6) 相关.
结论:
- 流行病后的时代显示,小儿ARTIs中的HBoV1增加和流感减少.
- HBoV1不独立与严重疾病相关;同时感染,特别是RSV,增加发病率.
- 研究结果强调需要持续的病毒监测和适应性临床策略对儿科呼吸道感染.
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