设计瘤微环境:瘤性NDV以促进CAR-T细胞治疗
Mei Wang1,2, Ke Jiang1,2, Alexandra Aicher3
1Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of translational medicine
|November 19, 2025
概括
纽卡斯尔病病毒 (NDV) 通过重新编程瘤微环境,增强了固体瘤的仿真抗原受体 (CAR) -T细胞疗法. 这种组合疗法有望克服癌症治疗当前的局限性.
科学领域:
- 免疫治疗是一种免疫疗法.
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 卡尔-T细胞疗法在血液癌症中取得了成功,但由于抗原异质性,透性差,免疫抑制性瘤微环境 (TME) 而与固体瘤作斗争.
- 瘤病毒 (OV) 可以修改TME并提高CAR-T细胞的疗效,但人类血清流行率和安全性等挑战限制了它们的使用.
- 纽卡斯尔病病毒 (NDV) 是一种自然选择性瘤的鸟类病毒,提供了一个安全有效的平台,具有最小的先前存在的人类免疫力.
研究的目的:
- 审查将NDV与CAR-T细胞治疗结合在一起的理由和临床前证据.
- 探索NDV的潜力,以克服固体瘤治疗中的挑战.
- 讨论这种协同方法的翻译前景.
主要方法:
- 对NDV在调节TME中的生物机制的审查.
- 对NDV-CAR-T细胞组合疗法的临床前数据的分析.
- 评估NDV的有效载荷传递能力,用于增强免疫治疗.
主要成果:
- NDV诱导直接杀死瘤细胞和免疫细胞死亡.
- NDV通过激活像树突细胞和巨细胞这样的免疫细胞来重塑TME.
- 工程NDV可以提供免疫刺激的有效载荷,潜在地改善CAR-T细胞的持久性和对抗疲劳.
结论:
- 在固体瘤中,NDV提供了一种有前途的策略来增强CAR-T细胞疗法.
- 结合NDV和CAR-T细胞,为有效的癌症治疗创造了一个更宽容的TME.
- 进一步对NDV进行工程可能有助于推进固体瘤免疫疗法.
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