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来自Haemonchus contortus的ES15-1通过调节STAT3/RORγt通路来促进山羊的Th17反应

Cheng Chen¹, Jiajun Feng¹, Jilata Amu¹

¹Ministry of Education (MOE) Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

Veterinary research

|November 19, 2025

概括

来自Haemonchus contortus的ES15-1通过激活STAT3/RORγt通路来刺激Th17免疫反应. 这种类疫苗接种显著减少了山羊的寄生虫卵数和虫负担,为控制H. contortus感染提供了潜力.

科学领域:

免疫学免疫学免疫学
寄生虫学的寄生虫学
分子生物学分子生物学

背景情况:

Th17细胞对于抗感染性免疫非常重要.
海蒙丘斯形虫排泄/分泌蛋白15 (HcES-15) 是一个潜在的疫苗候选者.
来自HcES-15的特定可以选择性地诱导Th17反应.

研究的目的:

为了识别和描述诱导Th17免疫反应的HcES-15中的.
评估ES15-1在给予对H.contortus感染的免疫保护方面的有效性.

主要方法:

HcES-15衍生的放大和表达 (ES15-1,ES15-2,ES15-3). 这两种类型的蛋白质是:
在体外评估山羊PBMC中的STAT3/RORγt通路激活和IL-17产生.
在小鼠和山羊体内使用PLGA封装ES15-1的研究,包括流细胞计,ELISA,便卵数减少和虫负担评估.

主要成果:

ES15-1激活了STAT3/RORγt通路,并在体外诱导IL-17的产生.
在小鼠中,皮下注射PLGA-ES15-1增强了Th17细胞分化和促炎细胞因子水平 (IL-17,IL-1,IL-6,TNF-α).
接种疫苗的山羊在H.contortus感染后的便卵数 (69.0%) 和虫负担 (50.54%) 显著降低.

结论:

体ES15-1通过STAT3/ROR路调节有效地增强Th17反应.
在山羊中,ES15-1疫苗接种提供了对Haemonchus contortus的显著免疫保护.
ES15-1代表了开发针对寄生虫线虫感染的疫苗的有希望的候选人.

关键词:

海蒙丘斯 (Haemonchus contortus) 是一个长长的鱼类.在ES-15中使用ES-15.在STAT3/RORγt路径中.Th17 的反应反应.

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