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Updated: Jan 11, 2026

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Bmi1通过全基因组H3K27me3修改控制听觉感官上皮细胞的增殖

Xiaoling Lu1, Yunzhong Zhang1, Ruofei Dai2

  • 1Department of ENT Institute and Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai, 200032, People's Republic of China.

Epigenetics & chromatin
|November 19, 2025
PubMed
概括

在新生小鼠中,Bmi1蛋白减少会通过改变基因表达和染色质可访问性而导致毛细胞脱落. 抑制Cdkn2c可以挽救细胞增殖,为听力损失提供治疗点.

关键词:
在BMI1上.细胞的增殖细胞的增殖.H3K27me3 在线阅读听力损失 听力损失基因组胺基因的修改内耳是指内耳的内部部分.

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