在吸烟引起的COPD中,TIGIT/SHIP-1/RelB调节了Th1炎症
Junyi Ke1,2, Siyu Lei1,2, Zhixiong He1
1Guangxi Medical University, Nanning, Guangxi, China.
Respiratory research
|November 19, 2025
概括
在吸烟引起的COPD中,TIGIT/SHIP-1通过PI3K/AKT信号调节RelB,控制Th1炎症. 这揭示了COPD病变发生过程中的关键免疫机制.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性阻塞性肺病 (COPD) 涉及各种免疫细胞介导的呼吸道炎症.
- Th1型过敏反应有助于COPD中不可逆转的气道损伤.
- TIGIT (T细胞免疫球蛋白和ITIM域) 受体及其下游酸酶SHIP-1通过氨酸酶途径调节CD4+T细胞免疫力.
研究的目的:
- 研究吸烟引起的COPD中CD4+T细胞中的TIGIT/SHIP-1表达模式.
- 阐明TIGIT/SHIP-1如何影响CD4+T细胞和Th1炎症的机制.
- 为了确定COPD中由TIGIT/SHIP-1调节的下游信号通路.
主要方法:
- 我们使用了吸烟引起的COPD的临床和动物模型.
- 采用了流细胞计,免疫光和染色体免疫沉.
- 进行了单细胞和大量RNA测序生物信息学分析.
主要成果:
- 在COPD中CD4+T细胞显示TIGIT/SHIP-1表达的增加.
- 淘汰CD4-Tigit或SHIP-1抑制导致小鼠Th1水平升高.
- RelB被确定为COPD-Th1炎症的关键调节剂,通过PI3K/AKT信号传递作用于TIGIT/SHIP-1的下游.
结论:
- TIGIT/SHIP-1通过PI3K/AKT通路调节RelB激活来调节COPD中的Th1表达.
- 这项研究提供了对COPD病原体背后的免疫机制的新见解.
- 针对TIGIT/SHIP-1/RelB轴可能为COPD提供治疗策略.
相关概念视频
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
COPD: Management Using Bronchodilators and Corticosteroids
706
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
706
Chronic Obstructive Pulmonary Disease-I: Introduction
3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K


