相关实验视频
Updated: Jan 11, 2026
13:01
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
137.1K
抗卡斯普2抗体的异质性:特异性和致病性
Julia Su1, Rohan Gupta1, Scott van Hoof2,3,4
1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Translational psychiatry
|November 19, 2025
概括
针对接触因相关蛋白类2 (Caspr2) 的母体抗体对胎儿大脑发育有多种影响. 不同的Caspr2抗体在雄性小鼠后代中产生了明显的自闭症谱系障碍类行为变化.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 母亲抗卡斯普2 (Contactin相关蛋白类2) 抗体与自闭症谱系障碍 (ASD) 的风险增加有关.
- 在子宫内暴露于抗卡斯普2抗体之前已经在雄性小鼠中诱导了类似ASD的特征.
研究的目的:
- 调查四种新型抗卡斯普2抗体在发育中的胎儿大脑上的病原性.
- 为了确定这些抗体是否通过类似的机制起作用.
主要方法:
- 对Caspr2.2产生了四种新的抗体.
- 孕期小鼠在子宫内暴露于这些抗体.
- 评估男性后代的行为表型,使用社会互动,开放场地和明暗任务.
主要成果:
- 新型抗卡斯普2抗体识别了卡斯普2.2上不同的表位.
- 在子宫内暴露导致男性后代的差异性行为表型.
- 观察到的变化包括社会互动,探索和与焦虑相关的行为.
结论:
- 反Caspr2抗体的抗原特异性和病原性存在显著的变异性.
- 这些发现凸显了母亲对神经发育抗体影响的复杂性.
- 不同的致病性可能对理解ASD风险具有重要的临床影响.
更多相关视频
11:10Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
14.5K
10:16Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
Published on: September 15, 2016
13.2K
相关概念视频
00:42Cross-reactivity
32.8K
Overview
32.8K
01:28Diversity of Antigen Receptors
1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K
01:26Antigens Involved in Adaptive Immunity
1.3K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.3K